Interestingly, low levels of anandamide and high levels of fatty acid amide hydrolase, the enzyme that degrades anandamide, are detected after ovulation during the luteal phase in the peripheral lymphocytes of normally cycling, non-cannabis smoking females Lassarin et al, As they watch the balloons voyage to the other side of the rainbow bridge, they learn to positively process their grief Only one sex difference study in rats has reported a significant THC-induced increase in locomotor activity, and this was observed in females only, at the lowest THC dose tested Wiley and Burston, Cbd Care 4 Pets The Balance Harness — Buckle-Neck has 6 adjustment points offering a customized fit for comfort, complete freedom of movement, and flexible leash attachment options Accurate assessment of pharmacotherapies to target sex-specific withdrawal symptoms can be best examined under these circumstances Accurate assessment of pharmacotherapies to target sex-specific withdrawal symptoms can be best examined under these circumstances. If your dog consumes too much THC, it could feel sluggish or tired, and in extreme cases could lose motor skills and end up vomiting Walkee Paws don't squeeze; they connect around your dog's back meaning that they can adjust as your dog grows, too! Say goodbye to muddy paws and funny dances Understanding how men and women differ in regard to incidence and severity of withdrawal symptoms during abstinence can help to guide research into sex-specific pharmacotherapies for cannabis dependence, increasing treatment success for both men and women Offering certain raw food products provides pets the foundation for a diet that resembles one akin to their diet in the wild Significant differences in methods of use also emerged, with more women than men reporting using edible cannabis preparations, whereas men more frequently reported using joints, blunts, vaporizers, and concentrates Cuttler et al, Significant differences in methods of use also emerged, with more women than men reporting using edible cannabis preparations, whereas men more frequently reported using joints, blunts, vaporizers, and concentrates Cuttler et al, . SodaPup has developed a range of enrichment products including enrichment mats eMats , enrichment coins eCoins , enrichment trays eTrays and enrichment bowls eBowls These findings agree with earlier reports demonstrating that women report greater withdrawal symptom severity relative to men Among daily cannabis smokers, females were more sensitive than males to subjective effects related to abuse liability, including ratings of drug liking and willingness to take the drug again Cbd For Pets Sign The safest way to treat your pet with CBD oil is to stick with trusted brands with positive customer reviews Data from surveys, laboratory-based studies, and one study in a clinical population suggest that men and women may differ in their responses to cannabinoids, yet the direction of this sex difference may depend on the End points used and the population studied patients, non-cannabis-using healthy controls, or cannabis-using healthy controls Data from surveys, laboratory-based studies, and one study in a clinical population suggest that men and women may differ in their responses to cannabinoids, yet the direction of this sex difference may depend on the End points used and the population studied patients, non-cannabis-using healthy controls, or cannabis-using healthy controls. Learn what goes into creating a new pet product and taking it to market .

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However, few of these studies speak to the possible sex-dependent nature of cannabis and cannabinoid effects, with most testing only one sex or not including sex as a factor in data analysis Recent efforts have sought to elucidate differences in efficacy of FDA-approved therapeutics between men and women to better help guide treatment decisions Using only those gifts, we craft each of our products with the individual love and attention that everyone deserves Systemically administered rimonabant, a CB1 receptor-selective antagonist, was significantly more potent in females than males in blocking the acute antinociceptive effects of systemic THC and CP55, Craft et al, , suggesting that rimonabant has greater affinity for the CB1 receptor in females than males Systemically administered rimonabant, a CB1 receptor-selective antagonist, was significantly more potent in females than males in blocking the acute antinociceptive effects of systemic THC and CP55, Craft et al, , suggesting that rimonabant has greater affinity for the CB1 receptor in females than males. The only significant sex difference among the many withdrawal symptoms assessed was that females showed more retropulsion walking backwards than males did Marusich et al, THC administration Wall et al, Remember, every living creature has its own unique biochemistry, and as such may feel varying degrees of effects from ingesting cannabinoids Cbd Pets Itch Local intraplantar THC administered to CFA-treated female and male rats also produced greater anti-allodynic and anti-hyperalgesic effects in females, suggesting that sex differences in peripheral cannabinoid function contribute to sex differences in cannabinoid antinociception Literature addressing the effects of adolescent cannabinoid exposure on adult behaviors and cannabinoid sensitivity is not included in this review, nor is the clinical literature on sex differences in cannabis use and brain structure, as these topics have been recently reviewed elsewhere eg, Viveros et al, , ; Ketcherside et al, ; Dow-Edwards and Silva, Literature addressing the effects of adolescent cannabinoid exposure on adult behaviors and cannabinoid sensitivity is not included in this review, nor is the clinical literature on sex differences in cannabis use and brain structure, as these topics have been recently reviewed elsewhere eg, Viveros et al, , ; Ketcherside et al, ; Dow-Edwards and Silva, . What more of a better way to show our love for our pets than to have a custom AugiDog canvas to hang in our home, or office of our furry best friends In gonadally intact female rats, acute antinociceptive sensitivity to THC also has been shown to fluctuate across the estrous cycle, with peak sensitivity to THC at the time of ovulation or shortly thereafter Craft and Leitl, ; Wakley et al, These studies assessed a range of therapeutic End points as a function of treatment with various CB1 agonists, including oral THC dronabinol , nabilone, or cannabis containing THC, and various routes of administration including smoked, vaporized, and oral In animals, several cannabinoid receptor agonists that act at the CB1 receptor, including THC the primary psychoactive constituent of cannabis , its primary active metabolite OH-THC, and the synthetic cannabinoid CP55, have been shown to be more potent in female compared to male rats on tests of acute thermal and mechanical pain Tseng and Craft, ; Romero et al, ; Craft et al,

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Since , Friends of Miami Animals Foundation has been a leader in animal welfare issues Since , Friends of Miami Animals Foundation has been a leader in animal welfare issues. Known as Pseudocoprostasis, this problem involves feces and hair becoming matted in the fur around the anus area THC-induced antinociception against acute thermal pain in late proestrous female rats compared to males Wakley and Craft, , suggesting that a second locus of sex differences is supraspinal Never give your pet more than the recommended dosage suggested by your veterinarian or manufacturer One indication of severity of drug dependence is the presence and severity of withdrawal symptoms after cessation of cannabis use Every meal is hot-filled to ensure safety and flash-frozen to lock in freshness Every meal is hot-filled to ensure safety and flash-frozen to lock in freshness. Its unique design offers you the flexibility of multiple adjustment points to ensure that your dog has a properly fitting harness to ensure comfort, proper movement, and safety Analgesia Although sex differences in cannabinoid-induced analgesia have not been assessed in a patient population, these differences have been explored in one study of healthy participants A third study examined spontaneous withdrawal symptoms after termination of chronic THC treatment of adolescent rats How Much Cbd Can You Give Pets Rob Silver to talk about the active ingredients in various types of mushrooms and how they can be a great addition to our pets' health routines .

Their hearty meals include an array of fresh ingredients Their hearty meals include an array of fresh ingredients. Formulated by veterinarians, DoggyRade is a low-calorie isotonic drink with a great chicken taste profile that dogs love Chemotherapy-induced nausea A significant proportion of randomized, placebo-controlled studies of the therapeutic utility of cannabinoids has investigated their effectiveness for chemotherapy-induced nausea and vomiting, and HIV- and cancer-related cachexia Whiting et al, , yet few studies have analyzed sex-dependent differences in these clinical End points Now that the weather is warmer, Justin is getting ready for his next hike with Maggie No appointments Furthermore, increases in methylphenidate-induced glucose metabolism were apparent in the female healthy controls but not in the female cannabis users Furthermore, increases in methylphenidate-induced glucose metabolism were apparent in the female healthy controls but not in the female cannabis users. No studies to date have investigated differences between men and women in THC pharmacokinetics after smoked cannabis administration The analgesic and antihyperalgesic effects of nabilone 0 That is, female cannabis users exhibited lower glucose metabolism after placebo administration relative to female healthy controls, an effect that was not observed when comparing cannabis-using men to non-cannabis-using men Is Pet Cbd Oil Safe This study did not specify if men and women differed in current cannabis use Additionally, prevalence rates of CUD are higher among males relative to females during adolescence Hayatbakhsh et al, , and see Farmer et al, : lifetime prevalence rates of DSM-IV cannabis abuse or dependence from 16 to 30 years of age was Additionally, prevalence rates of CUD are higher among males relative to females during adolescence Hayatbakhsh et al, , and see Farmer et al, : lifetime prevalence rates of DSM-IV cannabis abuse or dependence from 16 to 30 years of age was . Our mg Pet Lover Tincture is an ideal starting point, especially for little ones, as you determine how much CBD your pet needs .

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A recent study sought to study incidence and severity of withdrawal symptoms as a function of sex during a cannabis quit attempt in a population of treatment-seeking cannabis users Herrmann et al, Show Notes Episode - Unexpected Pet Expenses This week Michelle Fern is joined by Jonathan Wainberg, senior vice president and general manager, Pets, Synchrony to talk about the cost of pet ownership and how to help with the veterinary costs when something unexpected happens Focus makes it easy to teach new commands and fix behavior problems Help your dog put their best foot forward with Walkee Paws, the new innovation in dog-walking that allows them the freedom and range of motion that dog boots don't! We've all seen dogs do that funny dance when trying boots or socks because they squeeze the dog's feet to stay on, which causes discomfort and can restrict their movement Help your dog put their best foot forward with Walkee Paws, the new innovation in dog-walking that allows them the freedom and range of motion that dog boots don't! We've all seen dogs do that funny dance when trying boots or socks because they squeeze the dog's feet to stay on, which causes discomfort and can restrict their movement. Show Notes Episode - Dr KittyRade is a healthy prebiotic drink that encourages reliable hydration in cats This sex difference in OH-THC production is modulated by gonadal hormones Craft et al, , observed in adolescent as well as adult rats, and increases in magnitude with repeated THC treatment Wiley and Burston, Love Hemp Cbd Oil For Pets However, this sex discrepancy may reflect heavier cannabis use reported among men relative to women ie, Cuttler et al, rather than a sex-specific sensitivity to this adverse effect of cannabis Details of animal and human studies are shown in Table 1 Details of animal and human studies are shown in Table 1. Instructions: Place ingredients into a blender and thoroughly mix

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It is based on 70 years of research and experience, thousands have used it with tremendous proven results Dogs love chewing and sniffing Michelle Fern welcomes Kerry Cooke, creator of this amazing new product! Dogs get dehydrated, just like people do! When Fido starts panting halfway through your walk Medi Pet Cbd Oil They are designed in fun with some wordplay, and comfy as they are long-lasting Abuse-related subjective effects Sex differences in response to the acute effects associated with abuse liability of cannabis and cannabinoids have been examined using double-blind, placebo-controlled laboratory procedures Abuse-related subjective effects Sex differences in response to the acute effects associated with abuse liability of cannabis and cannabinoids have been examined using double-blind, placebo-controlled laboratory procedures. Litter box clean-up is already the least liked chore by cat parents Given that peri-pubertal ovariectomy of female rats can also modulate cannabinoid sensitivity Winsauer et al, ; Winsauer et al, ; Winsauer and Sutton, , and administration of the same hormone to adult male and female gonadectomized rats does not change cannabinoid sensitivity in the same way Craft et al, , it is likely that organizational gonadal hormone milieu and possibly sex chromosomes also contribute to sexual differentiation of cannabinoid sensitivity They help build effective programs, establishing meaningful collaborations and engaging leaders and the community to save and improve the lives of homeless pets There have also been recent reports of intense bouts of vomiting and gastrointestinal distress in chronic cannabis smokers, called cannabinoid hyperemesis syndrome CHS ; whether these cases are recreational or medical cannabis users is not clear Withdrawal Although women and men report similar patterns of cannabis use, women seeking treatment for problematic use score higher on a measure of severity of drug dependence Copeland et al, Withdrawal Although women and men report similar patterns of cannabis use, women seeking treatment for problematic use score higher on a measure of severity of drug dependence Copeland et al, . Cannabinoid effects on fear- and anxiety-like behaviors can also be test-dependent Simone et al, This confusion over legality left pet parents with misconceptions about the safety of CBD for animals While these pharmacotherapies were not effective in reducing cannabis use relative to placebo for either sex, the authors found that women had worse outcomes relative to men in relation to cannabis craving and in difficulty achieving abstinence Pet Food Express Cbd Treats An early study investigated the effect of menstrual cycle phase on self-reported measures of mood, behavioral changes, and cannabis smoking in daily female cannabis smokers using daily diary entries; phase was estimated based on daily diary reports that tracked the onset of menses With smells that last at least 6 months, these long-lasting, naturally-scented dog toys pass the sniff test With smells that last at least 6 months, these long-lasting, naturally-scented dog toys pass the sniff test. Rates of cannabis use and problematic cannabis use ie, cannabis use disorder; CUD have also increased Hasin et al, ; for example, past-month cannabis use increased from 6 Peter Weinstein, veterinarian and former executive director of the Southern California Veterinary Medical Association to talk about keeping your cats safe in the sweltering summer heat! Joe Roetheli, creator of Yummy Combs Interestingly, considerable animal research suggests that cannabinoid treatment could be useful for alleviating chemotherapy-induced nausea and vomiting Rock and Parker, Overall, rodent studies indicate that females may be more sensitive than males to the effects of cannabinoids on movement .

Overall, rodent studies indicate that females may be more sensitive than males to the effects of cannabinoids on movement

A special note for dog owners and their unique endocannabinoid systems: Scientists have learned that dogs have more CB1 receptors in their brains than other animals A special note for dog owners and their unique endocannabinoid systems: Scientists have learned that dogs have more CB1 receptors in their brains than other animals. The objective of this review is to provide a translational perspective on the sex-dependent effects of cannabis and cannabinoids by synthesizing findings from preclinical and clinical studies focused on sex comparisons of their therapeutic potential and abuse liability, two specific areas that are of significant public health relevance These effects were assessed in response to smoked cannabis and oral THC in populations of non-cannabis users, light users, and heavy users These data suggest that THC differentially attenuates aspects of subjective responses related to continued cannabis use between men and women, and have implications for the use of THC as a potential pharmacotherapy for CUD Verita Farms Cbd Pet Oil Only one study in CB1 receptor knockout animals has been conducted Men and women appear to use medical cannabis for different reasons Men and women appear to use medical cannabis for different reasons. How do your pets feel about the kids being gone all day? What new pet products can help keep them happy and busy? Organic wheatgrass is regarded as a super potent health food with amazing benefits Blend well, so the CBD oil gets mixed evenly throughout each treat With spring here and summer quickly approaching, dust and pet hair will be unmanageable Just sweep up next to the EyeVac stationary vaccum and quickly clean your hard floors! Ideal for cleaning pet hair, salon hair, dirt and dust Several other behavioral effects of cannabinoids have been shown to be modulated by gonadal hormones in adulthood Several other behavioral effects of cannabinoids have been shown to be modulated by gonadal hormones in adulthood.

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Given the widespread use of cannabis for both medical and recreational purposes, and the emerging trend of more women using cannabis and cannabis-derived products, identifying potential sex differences in the therapeutic effects and risks associated with cannabis use is a public health imperative HandsOn Gloves are a revolutionary concept that reaches far beyond the traditional curry combs, mitts and shedders on the market today Of course, this would require an extremely large dose, nearing 1 What is PetHub and how do they do it? Learn what to do to protect them and what PetHub offers to keep them safe In a recent survey of patients diagnosed with a rheumatic condition, nearly half of respondents who reported of medical cannabis to treat symptoms were women Ste-Marie et al, In a recent survey of patients diagnosed with a rheumatic condition, nearly half of respondents who reported of medical cannabis to treat symptoms were women Ste-Marie et al, . Under placebo conditions, cannabis users exhibited lower glucose metabolism relative to healthy controls in the frontal cortex and anterior cingulate We also know they love their comfort! These felted wool cat cave beds are purrrfect for your happy kitty! Tune in! Show Notes Episode - How To Make Your Dog Famous We all know, love, and follow ridiculously fab dogs on social media - but how does your own fame-worthy pup reach influencer status? Petlibro has the perfect gift for the pet in your life this upcoming Holiday season! How many times have you rushed off to work, or anywhere, and wondered if you left food and water out for your pet? Petlibro has products proven to be technologically intelligent, and reliable, and has created a seamless way to keep pets healthy, hydrated, and well Thus, it would appear that sex differences in THC metabolism occur across species, although the differences may be larger in rats than in humans Their meals are made with high-quality, human-grade, whole food ingredients, which are more bio-available than fillers and other low-quality ingredients Sex differences in behavioral effects of cannabinoids have been observed on some End points in adolescent rats PND Romero et al, ; PND Harte and Dow-Edwards, and even in pre-pubertal rats PND28— Llorente-Berzal et al, ; but see Borcel et al, and Wiley et al, , suggesting that sex differences begin to develop early in life Sex differences in behavioral effects of cannabinoids have been observed on some End points in adolescent rats PND Romero et al, ; PND Harte and Dow-Edwards, and even in pre-pubertal rats PND28— Llorente-Berzal et al, ; but see Borcel et al, and Wiley et al, , suggesting that sex differences begin to develop early in life. Although subjective effects provide a measure of abuse potential, drug self-administration is the best measure of abuse liability because it best reflects drug-taking in the natural ecology Be with your pet even when you're away, and soothe your pet's anxiety for good Dingleberries are a very common problem for dogs, especially those with long fur A limitation of these studies is that assessments were based on retrospective self-report measures, requiring participants to recall from memory the incidence and severity of their withdrawal symptoms Catalyst shines sun in all the ways a great litter should so you can give your cat cat the best while doing your best for the planet Catalyst shines sun in all the ways a great litter should so you can give your cat cat the best while doing your best for the planet. This is most evident for studies examining the analgesic effects of cannabinoids in patient populations for various types of pain, including cancer pain Noyes et al, , chronic non-cancer pain Issa et al, ; Ware et al, , chronic neuropathic pain Karst et al, , multiple sclerosis-associated pain Svendsen et al, ; Rog et al, , HIV-associated neuropathy Abrams et al, ; Ellis et al, , postoperative pain Buggy et al, , chronic headache Pini et al, , post-traumatic or postsurgical neuropathic pain Ware et al, , neuropathic pain from spinal cord injury Wilsey et al, , and diabetic neuropathy Wallace et al, .

This review synthesizes findings from preclinical animal and clinical human sex difference studies guided by epidemiological findings that underscore two significant public health issues arising from changing legislation regarding cannabis for medical and recreational use: therapeutic potential and abuse liability In regard to cannabinoid-elicited nausea, Hempel et al showed that THC was more potent and efficacious in female rats compared to males in decreasing saccharin consumption in a conditioned taste aversion procedure, suggesting that females are more sensitive than males to the aversive effects of THC, or females were better than males at learning the drug-taste association which the authors concluded may be the case All of these products have benefits associated with slowing down eating and making your dog work for their food They also have a great Mission Statement as well! George C They also have a great Mission Statement as well! George C. The perfect combination of style and functionality: discreet, sanitary, and safe for indoor or outdoor use The first pet feeder of its kind, the Fluff Trough was invented by a dog mom looking for a better and safer way to feed her pug who struggled to eat from traditional feeders Dogs love to look out the window — whether it's at you coming home or another dog walking by However, sex-dependent effects were observed for ratings of compulsivity, with women exhibiting significant decreases on this measure after receiving either dose of oral THC, whereas oral THC failed to attenuate this rating in men Lundahl and Greenwald, But did you know that hemp oil can be used for pets too? It helps our pets too! Read on for more information But did you know that hemp oil can be used for pets too? It helps our pets too! Read on for more information. All with the ease and comfort of one easy-to-grip leash aid Show Notes Episode - Concha Collar .

Show Notes Episode - Concha Collar

Tune in to discover cool new products for your pawsome pooch or cool cat! Cue-induced craving Cannabis craving as a measure of addiction severity has been studied as a function of participant sex Despite the differences in cannabis-induced analgesia, men and women showed comparable subjective effects related to abuse liability Table 1 ; Cooper and Haney, Despite the differences in cannabis-induced analgesia, men and women showed comparable subjective effects related to abuse liability Table 1 ; Cooper and Haney, . This increase in medical cannabis use by women raises the question of whether its therapeutic efficacy differs as a function of sex It is not known to what extent sex differences in metabolism underlie sex differences in behavioral effects of cannabinoids besides THC While craving for, urge, and desire to smoke cannabis increased in response to the cues, differences between men and women were not detected Lundahl and Johanson, Buddy Custard is an all-natural remedy frozen treat to help dogs feel their best and boost their health, regardless of how healthy or ill the dog is

Finally, a comprehensive study of sex differences in brain endocannabinoid content in the rat revealed sex differences in multiple brain areas

Anja is a biotech scientist specializing in cartilage tissue engineering Anja is a biotech scientist specializing in cartilage tissue engineering. Michelle Fern talks about some cool products for having a safe and fun summer with your pets! Marty Becker together with his daughter, lead animal trainer for Fear Free Pets, Mikkel Becker in a fun and informative episode! Marty remembers how old Mikkel is and why he is calling the Elder Abuse hotline! What does coffee have to do with dogs? Now your pet can enjoy the taste of delicious cuisines from around the world! Visit pethealthconsult Your pets can benefit from functional mushroom supplements It's that time of year again! The Holidays are here and it's time to pamper your fur babe! We have an exciting show with everything from laser toys for cats to the ultimate luxury spa box for dogs! Listen to all the exciting and unique options for your fur babe or your granddog or grandcats When using any cannabis product, remember every ECS has slightly different needs These findings are directly relevant to the population using cannabis for medical indications, which varies in previous and current exposure to cannabis and cannabis-derived products These findings are directly relevant to the population using cannabis for medical indications, which varies in previous and current exposure to cannabis and cannabis-derived products. The dual lock mounting coins allow you to remove and replace the shield a breeze! The mission of Puppington is to help dogs enjoy healthier and happier lives by providing them with the purest, safest, and most effective ingredients With the growing acceptance of cannabis use for medical and recreational purposes have come widespread changes in cannabis availability, decreases in perceived risk, and expanding motivations for use Hasin et al, ; Compton et al, These pharmaceuticals can cause loss of appetite, digestive issues, depression, lethargy and more Greater decreases in locomotor activity have also been reported in adolescent female compared to male rats given CP55, Llorente-Berzal et al, and THC Harte and Dow-Edwards, ; however, the sex difference with THC is not always observed and may depend on the age at which young rats are tested, as well as procedural factors Harte and Dow-Edwards, ; Harte-Hargrove and Dow-Edwards, ; Wiley et al, Few cannabinoids have been compared in females vs males using models of persistent pain, which are likely to be more predictive of cannabinoid analgesic potential in humans Few cannabinoids have been compared in females vs males using models of persistent pain, which are likely to be more predictive of cannabinoid analgesic potential in humans. This lack of information leaves pet owners questioning if CBD could help their furry family members No studies have been conducted to determine whether neonatal gonadectomy, a method typically undertaken to examine organizational effects of gonadal hormones, abolishes sex differences in behavioral effects of cannabinoids Spend more quality time with your furry friend and less time cleaning up after them with the EyeVac Pet However, sex differences are not entirely consistent across studies for the same brain area, and some studies report no sex differences in some of these same brain areas eg, Rodriguez de Fonseca et al, ; Riebe et al, ; Casteels et al, ; Castelli et al, , suggesting that methodological details such as how rats are handled ie, stress , what estrous stage females are in, and various biochemical parameters of the mRNA or protein assay may be crucial Our animal companions are super vulnerable as well Our animal companions are super vulnerable as well. Sure Petcare products are Microchip and app-controlled cat doors and feeders, and life-changing pet technology Komen Foundation Dog Rocks will help stop pet urine burn patches ruining your lawn, grass and hedges .

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However, for objective measures of pain, cannabis elicited greater analgesia compared to placebo-cannabis in men relative to women: men exhibited a robust analgesic response as measured by latency to feel pain, whereas women did not

It contains a carbon lining that helps trap the foul odor from dog droppings Marty Goldstein, to talk about his line of pet products, his books, and his recent documentary, The Dog Doc In addition to these presumably genomic slower effects of gonadal hormones, rapid membrane estrogen receptor ER -mediated effects on the cannabinoid system have been documented A second study assessing sex-dependent subjective effects of smoked cannabis matched men and women according to current cannabis use Cooper and Haney, A second study assessing sex-dependent subjective effects of smoked cannabis matched men and women according to current cannabis use Cooper and Haney, . This study carefully controlled for cannabis dependence inclusion criteria, excluded other drug dependencies eg, alcohol and characterized participants based on amount of cannabis use in the previous 90 days, ensuring that men and women were matched for current cannabis use While men and women had similar patterns of cannabis use, women were more likely to have psychiatric diagnoses and reported lower quality of life compared to men, which may have contributed to differences in self-reported incidence and severity of withdrawal symptoms Direct sex chromosome influence has not yet been investigated for any cannabinoid effect The Enhanced Pet Bowl not only allows your pet to enjoy their meal, it extends their lifespan by reducing these health problems For example, endocannabinoid tone has been shown to vary across the menstrual cycle For example, endocannabinoid tone has been shown to vary across the menstrual cycle. When the Farm Bill of recognized CBD extracted from industrial hemp as safe for human consumption, there was no such legalization for animals Future studies should examine withdrawal symptoms according to both self-report and clinician-based assessments in real time, optimally after participants have been exposed to a known quantity and strength of cannabis A later survey similarly assessed sex differences in self-reported withdrawal symptoms and also found that more women reported nausea and anxiety, whereas men more frequently reported sleep disruptions Cuttler et al,

However, recent studies investigated the potential for sex-dependent treatment effects with the selective serotonin receptor inhibitor and partial 5-HT1A agonists, vilazodone and buspirone, for cannabis dependence McRae-Clark et al, , Listen to Episode Now: Show Notes Episode - Dandylion As more people embrace the importance of clean and fresh dog care, Dandylion, the innovative brand has taken the market by storm, and is now the 1 New Release in Pet Supplies on Amazon Beyond sex differences in cannabinoid receptor pharmacology, there is growing preclinical evidence that gonadal hormones, particularly estradiol, may influence cannabinoid receptor density or function First, female rats of two strains acquired stable drug self-administration faster, self-administered more of the synthetic cannabinoid agonist WIN55, during the maintenance phase, took longer to extinguish responding when vehicle was substituted for WIN55,, and showed greater drug- and cue-primed reinstatement than males Fattore et al, , One collar tag is supplied with the product Everyone loves their pets like they are family, because in reality, they are Thus, even when treated with lower doses than males, females developed greater tolerance than males

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Tune in to hear about all the cool Catit fountains and products! Michelle Fern welcomes Dr Vet approved and eco-friendly! Evermore Pet Food carefully crafts recipes that rival the best home-cooked dog food Additionally, we do not yet know whether sex differences in cannabinoid antinociception occur at other levels of the neuraxis, for various types of pain Rich in vitamins, antioxidants, and fiber, they also support the digestive system, as well as promote anti-inflammation and dental health They are a collectible line of charms that attach to quality leather collars and leashes for pets with personality — and every pet is unique — so their collar should be, too! The Safety Dog Leash is a safety accessory that attaches to any leash allowing you to have your hands free while walking or dog or multiple dogs One study demonstrated greater intracerebroventricular i These attachable anchors allow the waste bag to be draped over the edge of the litter box for easy clean up In this double-blind, placebo-controlled study, healthy, and daily cannabis smokers were recruited, and the effects of smoked cannabis with THC active cannabis vs placebo cannabis cannabis with no THC were determined using the Cold Pressor Test, a laboratory pain assay that has predictive validity for clinically effective analgesics used for chronic pain In summary, the few studies that have examined sex differences in the development of tolerance to cannabinoids suggest that females develop tolerance more readily than males to the antinociceptive effects of THC, but there are very few studies of tolerance development to cannabinoid effects other than antinociception Super easy to use, the dooloop frees your hands for better things, morning coffee, ringing phone, waving to a friend, holding an umbrella, or best, holding hands with someone you love Balloons for Tiger takes an imaginative look at this tough topic as colorful balloons travel from the hands of children to their beloved cat who has passed on Whether you're hiking in the deep woods, or running along a city street - make sure your four-legged companion is highly visible and safe with Spot the Dog reflective wear! Spot The Dog collars are not only easy fastening so you have more time to play with your pet; but they also come in a wide range of sizes to fit your four-legged friend, large or small Some dogs are more social, others less, with DogPack you decide who your best friend interacts with Mammals, birds, reptiles, amphibians, and fish all have endocannabinoid systems Betsy Redmond, Chief Science Officer for Innovative Pet Lab - an at-home pet diagnostic company focusing on gut health testing for dogs and cats The connected app monitors usage frequency and allows for custom settings .

More research is needed to truly determine its efficacy, but researchers agree that wheatgrass has potential Really Great Cat Litter is made from soybean byproduct that would have otherwise gone to the landfill — safer for your cat, better for the planet Show Notes Episode - Enhanced Pet Bowl Imagine a bowl designed for pets that causes less bloating, less of a mess, and most importantly, promotes a healthier lifestyle For example, females had greater 2-AG levels than males in hypothalamus and pituitary, and lower 2-AG levels in cerebellum, and estrous cycle-dependent sex differences were additionally found in hippocampus anandamide and midbrain 2-AG and anandamide; Bradshaw et al, End points that have been assessed include subjective drug ratings related to positive drug effects and cue-induced craving Women exhibited greater sensitivity to the lowest THC dose tested 5 mg and reported higher ratings related to abuse liability, including ratings of drug liking, desire to take the dose again, and good drug effect They function similarly to how our human ECS works — by maintaining overall balance within the body Mechanisms underlying sex-dependent effects of cannabinoids Gonadal Hormones Sexual differentiation of cannabinoid sensitivity could arise from the direct influence of sex chromosomes eg, genes on the X vs Y chromosomes that control cannabinoid receptor expression , or indirectly from organizational early developmental or activational pubertal to adult effects of gonadal hormones on the endocannabinoid system Becker et al, Clinical trials for CUD Clinical trials investigating potential pharmacotherapies to treat CUD do not typically assess outcomes according to sex recent studies include Allsop et al, ; Levin et al, Although intrathecal cannabinoids can be effective analgesics in male Gu et al, ; Brownjohn and Ashton, and female Cui et al, rats or mice, we are not aware of any studies comparing spinal cannabinoid antinociception between males and females of any species They have developed a refreshing treat using a palatable formula to encourage hydration NewRoad Foods offers fresh, human grade dog food, delivered No changes in cannabis use were detected as a function of menstrual cycle phase follicular, periovulatory, luteal, premenstrual, and menstrual phases over three cycles Griffin et al, Maybe they just need to beat the heat and soothe their joints after a long walk A survey of cannabis users found that of those using cannabis for medical purposes, women were more likely than men to report that they used it to help alleviate anxiety, nausea, anorexia, irritable bowel syndrome, and headache Cuttler et al, And, of course, you should always talk to your veterinarian before starting your pet on a new treatment plan In response to the methylphenidate challenge, cannabis users exhibited blunted regional metabolism compared to healthy controls; moreover, regional increases in glucose metabolism in response to methylphenidate were negatively correlated with addiction severity Then drop us a comment below .

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The increased popularity of cannabis for medical purposes and the narrowing gap in prevalence of use between men and women raises questions regarding sex-dependent effects related to therapeutic efficacy and negative health effects of cannabis and cannabinoids

Made from dog-safe materials, find a wide variety of dog toys that match your pet's play style In summary, there is growing evidence that sexual differentiation of cannabinoid drug sensitivity is due at least in part to activational effects of gonadal steroid hormones While powerful at removing chemical, sweat, mildew, perfume, and pet odors, our formulation is consciously crafted without any toxic additives, dyes, or fragrances to be gentle on your skin, your fabrics, and the planet In this study, nabilone did not reduce pain intensity relative to placebo Lilly Brush offers a complete line of successful pet hair removers that trap soft clingy undercoat hair with every sweep The increase in risk observed among men relative to women may not be due to biological underpinnings, but rather due to social factors that limit exposure to cannabis and decrease the likelihood of cannabis initiation and use in females, including greater perception of risk, decreased cannabis use among peers, and greater childcare responsibilities In addition, it is not clear whether cannabis exposure immediately prior to the quit attempt was comparable among men and women One recent survey on perceived efficacy of cannabis to treat a variety of medical conditions found that men reported more relief from headache relative to women Cuttler et al, For example, if you have a pound dog with arthritis pain, consider playing it safe by starting with 0 Inspired by our experiences, we are motivated by a collective desire to help others on a unified journey to find peace and harmony within ourselves, with one another, and with the world we all share .

Innovative Pet Lab tests offer pet owners and animal health practitioners peer-reviewed and scientifically-proven tests that help identify root causes of intestinal and autoimmune issues before they develop into more serious conditions For example, WIN55,induced hyperphagia in ovariectomized guinea pigs is attenuated by estradiol acting at both nuclear ER-alpha and membrane ER in hypothalamic neurons Washburn et al, Oral THC decreased cue-elicited craving and anxiety, an effect that did not differ between men and women Peak plasma anandamide levels are observed during ovulation and are positively associated with estradiol, luteinizing hormone, and follicle stimulating hormone suggesting that these hormones may play a role in regulating anandamide levels El-Talatini et al, Earlier studies examining withdrawal symptoms among non-treatment-seeking male and female cannabis users found that men and women reported different symptoms: women reported nausea, whereas men endorsed goose-bumps and cannabis craving Agrawal et al, ; Copersino et al, Clinical studies The potential clinical efficacy of cannabis and cannabinoids for various therapeutic indications is supported by findings from randomized, double-blind, and placebo-controlled studies Petpuls uses a proprietary algorithm in combination with a database of more than 10K bark samples from 50 breeds of dogs in four different sizes to detect and determine the five different emotional states of your dog —relaxed, anxious, angry, sad or happy One other study has reported a sex difference in peripheral antinociceptive effects of a cannabinoid: using a model of orofacial pain in which CFA is injected into the masseter muscle, a CB1-selective agonist was a substantially more potent and efficacious anti-allodynic agent in male rats compared to females Niu et al, Pet Life Radio listeners - Go to www Michelle and John talk about how it all started and what makes it so popular as well as his Doggos Doing Things book that is out now! This hilarious book pairs adorable photos of puppos of all shapes from smol flufferinos to long boys , sizes from big woofers to lil yippers , and breeds from puggos to labbers and huskos with ridiculous captions describing what they're up to

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The sample used for this study consisted of men and women who did not differ in cannabis use, with average use reported to be 4 Sex differences in liver enzymes involved in THC metabolism have also been documented in mice Watanabe et al, All this and more with the PetBidder app! Show Notes Episode - Celebration Conversation This week Michelle Fern has a fun chat with Dog For Dog's Henry Eshelman about all things holiday related, and some other topics that have nothing to do with the holidays but are amusing and interesting anyway! What happens when you put them all together? Something cool happens! Their t-shirt apparel feature songs, lyrics and bands with a furry spin Michelle Fern goes through some interesting Valentine's Day stats and facts plus cool Valentine gift ideas for your furry friends! The dooloop is a modern leash accessory for those who'd rather not walk around swinging bags of dog poop in hand Rob Silver — a Real Fun-guy! This week Michelle Fern welcomes Dr Best of all, you can test from the comfort of your home and at a time that works for you These innovative litter box anchors are perfect for cat parents tired of the same old litter box routine Cannabinoids act at two types of cannabinoid receptors 1 CB1 and 2 CB2 , with many addiction-related and therapeutic effects known to be due to actions at the CB1 receptor Pertwee, In regard to cannabinoid dependence, several studies report sex differences in animals A great tool for any child who has experienced the loss of a pet- or any other loved one, too Our CBD tinctures for pets come in two strengths Other End points related to cannabis addiction severity Differences among men and women in neural correlates associated with severity of cannabis addiction were recently explored in a positron emission tomography PET study that measured brain glucose metabolism utilizing the radiotracer [18F]deoxyglucose .

Looking to reap the benefits of CBD for your furry friend? NuLeaf Naturals CBD hemp oil is versatile enough to be administered to dogs, cats, horses, and other animals A recent laboratory study compared the discriminative stimulus and subjective effects of oral THC in male and female non-treatment-seeking cannabis users This is also the case for most laboratory investigations of cannabinoid-induced analgesia in healthy populations Greenwald and Stitzer, ; Naef et al, ; Wallace et al, ; Kraft et al, ; Lee et al, b However, motoric effects are frequently assessed in animal studies of cannabinoid effect, and it is likely that dizziness contributes to altered movement However, a few sex difference studies examining acute cannabinoid effects in adolescent rats commonly defined as post-natal day PND 28—42, with males maturing slightly later than females Spear, are included, as these results suggest that sexual differentiation of cannabinoid sensitivity may occur well before adulthood for some cannabinoid effects Given that auto-immune disorders are more prevalent in women than men Klein and Flanagan, , determining whether the greater acute cannabinoid effects observed in female rodents compared to males on some relevant End points eg, inflammatory pain extend to models of auto-immune disease is warranted It can be used as an everyday health tonic and may even help treat specific diseases A significant gap in our knowledge regarding differences between men and women in relation to CUD is self-administration during non-abstinent and abstinent conditions, and a systematic assessment of withdrawal symptoms as a function of sex while controlling for cannabis exposure preceding cessation of use, as well as withdrawal assessments that include clinician-based ratings and objective measures Based on these findings, the authors suggest that cannabinoids may be helpful for women suffering from chronic pain These demographics are similar for other patient populations who use medical cannabis to alleviate symptoms other than pain .

However, epidemiological studies are showing that sex differences in cannabis use are shrinking, suggesting that societal constraints on cannabis use among females are abating Although it is difficult to recruit a balanced sample of each sex for human trials of auto-immune disease, one wonders whether the beneficial effects that have been reported thus far are due to the prevalence of women participants in these studies The Doggy Bathroom is the only dog litter box that keeps everything in one, easy-to-clean space with vertical pee pads Together, they create dopamine-boosting stimulation that dogs crave, need, and love Thus, the limited number of animal studies published to date suggests that female rodents are more sensitive than males to the reinforcing and discriminative stimulus effects of cannabinoids Cannabinoids such as THC, OH-THC, and CP55, have been reported to be more potent in decreasing spontaneous locomotor activity and lever-pressing, and increasing catalepsy in adult female rats compared to males Tseng and Craft, ; Craft et al, ; Weed et al, ; Wiley et al, Now you can find out! The test kits equip you with the knowledge to make informed decisions concerning the safety of your drinking water

In addition, these findings highlight the differences across studies that can emerge as a function of route of administration, a variable that should be addressed in future studies, particularly given the increasing popularity of edibles Cuttler et al,

Male but not female CB1 receptor knockout mice showed greater anxiety-like behavior than wild-type controls, despite the fact that rimonabant increased anxiety-like behavior in knockouts of both sexes Bowers and Ressler, , further suggesting that CB1 receptors may function differently in the two sexes

Help your cat stay hydrated by giving to your cat daily Pharmacokinetics In rats, sex differences in the metabolism of THC contribute to sex differences observed in behavioral effects of THC Women exhibited greater improvements in appetite under the medication conditions oral THC alone and the cannabis extract that included THC and cannabidiol , yet no sex differences were observed for other End points, including ratings of nausea or quality of life measures Strasser et al, The City Loo dog potty is the chic, modern and private indoor dog potty solution for your posh pet to use the bathroom on their schedule, wherever you are Women also reported greater symptom severity related to mood symptoms Pet parent and vet endorsed worldwide The Fluff Trough is vet-recommended and has everything you and your pet could ever want in a pet feeder Say goodbye to pesky pet hair and bring your furry friend anywhere with Lilly Brush Accidents can—and do—happen, so being prepared is crucial to keeping your pets safe In this study, cannabis cues increased ratings associated with compulsivity, or inability to control cannabis use, anxiety, and urge to smoke cannabis relative to a neutral cue The Toadfish Non-Tipping Dog Bowl sticks to any smooth surface to prevent the inevitable dog bowl flip! When you want to pick it up for a refill, simply lift it straight up to release the suction Other potential therapeutic effects for which there are not yet any analyses by sex While clinical literature suggests that cannabinoids have demonstrated therapeutic effects for the treatment of auto-immune disorders Ware et al, ; Notcutt, ; Katchan et al, ; Katz et al, , there are no sex difference studies of cannabinoid effects in animal models of auto-immune disease, despite single-sex studies demonstrating promising results eg, Malfait et al, ; Gui et al, ; Moreno-Martet et al, It also provides a great defense against off-leash animals approaching, with a foot spray distance! Michelle and Anna discuss some cool summer gift ideas including the Bearbark pet scratcher, PatPat pet themed kids clothes, That Blanket photo blankets, Petsies custom stuffed animals, Swiff Spray and more! Tune in to discover your favorite product! Show Notes Episode - Happy Ride Collapsible Travel Crate PetSafe brand, a global leader in pet product solutions, has made traveling with your pet even easier with the addition of the Happy Ride Collapsible Travel Crate to its robust line of travel products .

Potential therapeutic effects of cannabis and cannabinoids Preclinical Evidence for Sex-Dependent Effects Analgesia Given the demonstrated pain-relieving effects of cannabinoids in clinical trials Lynch and Ware, and the commonly reported use of cannabis to reduce chronic pain Bonn-Miller et al, ; Cuttler et al, , most preclinical sex difference studies published to date have focused on determining whether cannabinoids are equi-potent and -efficacious analgesics in females vs males Show Notes Episode - Stranger Things This week Michelle Fern talks about some of the strange and crazier pet products out in the market that you may or may not need for your pets! Michelle also answers email questions about her favorite pet products that have been featured on Best Bets for Pets Carlson Pet Products is a family-owned, budget-conscious, company specializing in creating pet safety products to keep your pet happily protected from the puppy stage through the senior years, such as pet pens, foldable elevated beds, crates, and pet gates They make food for dogs A later study of treatment-seeking cannabis users similarly found that women endorsed more withdrawal symptoms and negative impact of withdrawal symptoms relative to men who were matched for past-month cannabis use; sex differences in the severity of specific symptoms were found for hot flashes, headache, mood swings, irritability, gastrointestinal symptoms, and sleep disturbances Sherman et al, You can increase the dose slowly each week until symptoms subside THC-induced antinociception Wakley et al, in female rats ovariectomized as adults Together, these findings suggest that sex differences in THC-induced subjective effects depend on dose, route of administration oral vs smoked , and population cannabis users vs non-users These survey findings demonstrate that a significant proportion of the population using medical cannabis to treat specific symptoms are women, however, sex comparisons of self-reported efficacy of cannabis and cannabis-derived products are limited Rats were given either 2, 7 .

This unique book has more than antique and vintage dog photos with dog-voiced captions and unique Americana views, antique and vintage dog-themed advertisements, dog-voiced poetry, human-voiced poetry about dogs, and advice from good-old-dog Wilbur to the new pup generation Everyone aims for safe, natural, quality ingredients Early in withdrawal, males that had been treated with the higher doses of THC showed evidence of decreased anxiety whereas females showed evidence of increased anxiety Harte-Hargrove and Dow-Edwards, Freeman Introduction Over the last two decades, the policy landscape of cannabis legalization for medical and recreational use has undergone significant changes in the U Overall, limited evidence suggests that female rats may develop greater tolerance and greater cannabinoid dependence than males, although results may be end point-specific, and may also depend on the dose and duration of the chronic cannabinoid treatment Jeff Werber, host of Ask the Vets with Dr In summary, survey data suggest that women and men utilize medical cannabis at similar rates, although there is evidence that the symptoms for which they use medical cannabis differ, as do their methods of use Cuttler et al, Given that severity of withdrawal is hypothesized to contribute to ongoing use and relapse to use in a treatment setting Budney et al, ; Haney et al, , these studies suggest that women may experience greater difficulty than men achieving and maintaining abstinence from cannabis use Made with real meat, plus superfood ingredients like blueberries, carrots and pumpkin, the new Barkworthies Superfood Jerky treats for dogs help support muscle growth and development

A second study probed the potential utility of oral THC 10 and 20 mg for treating CUD in daily cannabis smoking men and women by determining its effects on cannabis cue-elicited craving Lundahl and Greenwald,

In animals, demonstrating anxiolytic effects of cannabinoids has been challenging, perhaps because cannabinoid effects on anxiety-like behavior are dose-dependent, with lower doses tending to be anxiolytic and higher doses tending to be anxiogenic eg, Rubino et al, ,

Pharmacological eg, cannabinoid metabolism and cannabinoid receptor density and hormonal mechanisms that may underlie sex differences in cannabinoid effects are briefly reviewed The new portable travel crate safely contains a dog in the backseat while heading to the next adventure Dogs need to start on the lower end of dosing measurements for hemp and build up over time as needed Studies with smoked cannabis reveal mixed effects Although sex-dependent therapeutic effects have not been assessed a priori, the following sections describe investigations that included exploratory assessments of drug effects as a function of sex, or that assessed sex differences in retrospective analyses of data pooled from several studies In contrast to studies of acute cannabinoid antinociception, gonadectomy and hormone replacement did not significantly alter the development of tolerance to THC-induced antinociception Wakley et al, , although flattening of the post-chronic THC dose-effect curves in this study limited the precision of tolerance quantification Hormonal and pharmacological mechanisms that may underlie sex differences in the effects of cannabis and cannabinoids are highlighted Patients were randomized to receive oral THC 2 No sex differences were detected in baseline craving Furthermore, estradiol-induced decreases in CB1 receptor signaling observed in the cortex and hippocampus of ovariectomized female rats were observed when estradiol was given acutely but not when it was given chronically Mize and Alper, .

Water resistant, leak proof and easy to clean, this dog poop bag is perfect for camping, hiking, long walks and other adventures This feeder is ideal for multi-pet households to prevent greedy pets becoming overweight and to ensure prescription or life-stage food is consumed by the right pet Multiple studies report that cannabis-dependent women experience more difficulty than cannabis-dependent men with withdrawal symptoms, a finding that is consistent with results showing enhanced negative effects of cannabis in women who are daily smokers, including increases in subjective effects that reflect abuse liability, and deficits in neurobiological markers associated with addiction severity Although THC dosing was not adjusted by body weight in this study, correction for sex differences in body weight did not eliminate the sex difference in metabolic indices, and blood levels of cannabinoids were also not correlated with BMI Nadulski et al, The first trip for the US market is set up to start in September and will reach Italy In a study of cannabinoid dependence rimonabant-precipitated withdrawal in gonadectomized and hormone-replaced adult male and female rats, it was concluded that estradiol and progesterone tended to promote dependence in females while testosterone tended to blunt dependence in males, although hormone effects tended to be subtle and inconsistent across End points Marusich et al, They prep and cook their meals in USDA kitchens, the same way human food is made This may help them from being bored in the house but it wreaks havoc on the window sill The only way to prevent, or reverse all the numerous infections and disease conditions that can develop in parrots directly caused by avian malnutrition is to feed a properly balanced avian food plan build around feeding Best Bird Food Ever Although epidemiological reports consistently demonstrate that men use cannabis more frequently than women Substance Abuse and Mental Health Services Administration, a , men seek treatment for cannabis use more often than women Substance Abuse and Mental Health Services Administration, b , and men are at higher risk for developing CUD Stinson et al, , a growing number of women report cannabis use for medical purposes McConnell et al, ; Finseth et al, ; Ryan-Ibarra et al, Their high standards extend beyond their product to how they treat their customers—they value you as much as your dog will value Evermore and that's A LOT .

Their high standards extend beyond their product to how they treat their customers—they value you as much as your dog will value Evermore and that's A LOT

In mice, which are more likely than rats to show cannabinoid-induced increases in locomotor activity, females but not males showed THC-induced increases in locomotion Wiley,

Men and women who smoked similar amounts of cannabis were presented with tactile, visual, and olfactory cannabis-related cues and were asked to rate their craving for, urge, and desire to smoke cannabis

Now, Fanny Foam solves this problem quickly and easily, and its proprietary formula makes cleanup a breeze A recent analysis sought to determine if cannabis-using men and women differed in cannabis-induced analgesia For every Dog Bowl sold, Toadfish donates a percentage of sales to coastal conservation and oyster restoration initiatives throughout the U The music player comes pre-loaded with nearly one hour of hz Wholetones music Women reported more withdrawal symptoms relative to men and had significantly higher scores on symptoms related to mood including increased restlessness, irritability and gastrointestinal symptoms nausea and stomach pain Remember, dogs are a little more sensitive to the sedative effects of hemp Attach Spleash to your favorite leash, and you can quickly refresh your pet with a squeeze of your finger without having to grab or carry anything other than your leash .